(For part 1 in the series, click here)

If macroevolution occurs, it must do so at the biochemical level.  Additional genetic information is needed to build the new proteins and biological systems required for large-scale changes.  Where does the new biological information come from?  Mutations?  No.  Point mutations such as inserting, inverting, or substituting nucleotides in existing genes cannot increase the information content of DNA even if they occur in protein-coding regions, and even if the mutations are beneficial to the organism.  At best they can only replace existing information/function with different information/function, so that the overall information content is merely preserved.[1]  For macroevolution to occur a net increase of information is required, not just a change in existing information.

The origination of new genetic information requires new proteins, which requires hundreds of additional nucleotides arranged in a highly specified order.  How likely is it that chance processes can get the job done?  Next to none.  The chances of producing a functional amino acid sequence of a mere 150 nucleotide bases (which would sequence one of the smallest proteins) is 1:10167.[2]  To put this number in perspective, consider that there have only been 10139 events in the entire universe since the Big Bang.[3]  So even if every event in the history of the universe was devoted to building a single functional protein, the number of sequences produced thus far would be less than 1 out of a trillion trillion of the total number of events needed to give it even a 50% chance of success!  Any reasonable person must conclude, then, that it is beyond the reach of chance to create even the smallest amount of new biological information in an organism.  Add to this the fact that many new proteins are needed to produce new biological systems, and the scenario becomes all the more fantastical.  If chance alone cannot produce the gene for even one protein—yet alone many—macroevolution becomes impossible.